X0609 4 2026-08-10 0 0001479615 Silence Therapeutics plc SLN 0001846370 Griffiths Richard Ian true ST HELIER Y9 Y9 JE2 3RR JERSEY 0 0 1 0 0 American Depositary Shares 16.00 2026-08-10 4 S 0 2792826 A Ordinary Shares 8378478 7488660 I See footnote American Depositary Shares 15.58 2026-08-10 4 S 0 100000 A Ordinary Shares 300000 7388660 I See footnote American Depositary Shares 16.09 2026-08-10 4 S 0 50000 A Ordinary Shares 150000 7338660 I See footnote American Depositary Shares 16.35 2026-08-10 4 S 0 3500 A Ordinary Shares 10500 7335160 I See footnote American Depositary Shares 16.00 2026-08-10 4 S 0 800000 A Ordinary Shares 2400000 6535160 I See footnote American Depositary Shares 16.00 2026-08-10 4 S 0 382000 A Ordinary Shares 1146000 6153160 I See footnote American Depositary Shares 16.09 2026-08-10 4 S 0 470820 A Ordinary Shares 1412460 5682340 I See footnote American Depositary Shares 16.00 2026-08-10 4 S 0 605174 A Ordinary Shares 1815522 5077166 I See footnote American Depositary Shares 16.00 2026-08-10 4 S 0 120000 A Ordinary Shares 360000 4957166 I See footnote American Depositary Shares 16.35 2026-08-10 4 S 0 60000 A Ordinary Shares 180000 4897166 I See footnote American Depositary Shares 16.00 2026-08-10 4 S 0 100000 A Ordinary Shares 300000 4797166 I See footnote Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date. The securities were sold by Cream Capital Limited ("CCL"), Blake Holdings Limited ("BHL"), Ora Ventures Limited ("OVL"), Ora Capital Limited ("OCL), Sarossa Plc ("SAR"), Pinkeys Limited ("PKL") and Mr. Griffiths personally. Mr Griffiths is a director and the controlling shareholder of CCL, BHL, OVL and OCL and the controlling shareholder of SAR and PKL. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein. /s/ Richard Ian Griffiths 2026-08-13