X0609 4 2026-06-23 0 0001814114 Orchestra BioMed Holdings, Inc. OBIO 0001722733 Pacitti David false C/O ORCHESTRA BIOMED HOLDINGS, INC. 150 UNION SQUARE DRIVE NEW HOPE PA 18938 1 0 0 0 0 Common Stock, par value $0.0001 per share ("Common Stock") 2026-06-23 4 A 0 17327 0 A 62295 D Common Stock 2026-06-24 4 F 0 3784 0 D 58511 D Stock Option (Right to Buy) 4.04 2026-06-23 4 A 0 21277 0 A 2036-06-23 Common Stock 21277 21277 D Represents an award of restricted stock units ("RSUs") awarded to the Reporting Person on June 23, 2026 (the "Grant Date"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs will vest on the one year anniversary of the Grant Date, subject to the Reporting Person's continuous service through such date. Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of RSUs. No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations. The stock options will vest on the one year anniversary of the Grant Date, subject to the Reporting Person's continuous service through such date. /s/ Andrew Taylor, Attorney-in-Fact 2026-06-25