X0609 4 2026-06-01 0 0001814114 Orchestra BioMed Holdings, Inc. OBIO 0001292834 Hochman David P false C/O ORCHESTRA BIOMED HOLDINGS, INC. 150 UNION SQUARE DRIVE NEW HOPE PA 18938 1 1 0 0 See Remarks 0 Common Stock, par value $0.0001 per share ("Common Stock") 2026-06-01 4 P 0 5000 3.83 A 1064029 D Common Stock 439482 I By the DPH 2008 Trust Common Stock 2000 I By the Solomon Ascher Hochman 2019 Trust Common Stock 2000 I By the Hannah Hochman 2019 Trust Common Stock 2000 I By the Judah Herman Hochman 2019 Trust Common Stock 3140 I By the NSH 2008 Family Trust The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.80 to $3.91. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. Chief Executive Officer and Chairperson /s/ Andrew Taylor, Attorney-in-Fact 2026-06-02