X0609 4 2026-05-15 0 0001814114 Orchestra BioMed Holdings, Inc. OBIO 0001376960 Aryeh Jason false C/O ORCHESTRA BIOMED HOLDINGS, INC. 150 UNION SQUARE DRIVE NEW HOPE PA 18938 1 0 0 0 0 Common Stock, par value $0.0001 per share 2026-05-15 4 P 0 8971 3.90 A 117453 D The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.70 to $4.03. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. /s/ Andrew Taylor, Attorney-in-Fact 2026-05-19