X0508 4 2026-03-12 0 0001781983 Aprea Therapeutics, Inc. APRE 0001716213 Hamill John P. 3805 OLD EASTON ROAD DOYLESTOWN PA 18902 0 1 0 0 SrVP/CFO/Prin Fin & Acct Ofcr 0 Common Stock 2026-03-12 4 A 0 10095 0.00 A 43528 D Stock Options (Right to Buy) 0.765 2026-03-12 4 A 0 40380 0.00 A 2036-03-12 Common Stock 40380 40380 D These shares represent restricted stock units and shall vest and be settled in the Issuer's common stock in three (3) equal annual installments beginning on March 12, 2027, until vested in full, subject to the reporting person's continued employment through and including the applicable vesting dates and subject to acceleration under certain conditions. Twenty-five percent of these options vest on March 12, 2027, with the remaining options vesting ratably over the following 36 months, subject to the reporting person's continued employment through and including the applicable vesting dates and subject to acceleration under certain conditions. /s/ John Hamill 2026-03-16