X0508 4 2026-02-24 0 0001425205 IOVANCE BIOTHERAPEUTICS, INC. IOVA 0002055001 Kirby Daniel Gordon C/O IOVANCE BIOTHERAPEUTICS, INC. 825 INDUSTRIAL ROAD, SUITE 100 SAN CARLOS CA 94070 0 1 0 0 Chief Commercial Officer 0 Common Stock 2026-02-24 4 M 0 120000 0 A 173546 D Common Stock 2026-02-24 4 F 0 34165 3.78 D 139381 D Restricted Stock Units 2026-02-24 4 M 0 150000 0.00 D Common Stock 150000 0 D Represents the number of shares of the Issuer's common stock underlying performance-based restricted stock units ("PSUs") that have been earned based on the level of achievement of certain financial milestones. The earned PSUs vested on February 24, 2026. Represents shares withheld by the Issuer to satisfy the mandatory tax withholding requirements upon vesting of the PSUs. This is not an open market sale of securities. Represents the common stock remaining after deducting the common stock withheld for taxes. Each PSU represents a contingent right to receive one share of the Issuer's common stock. On February 10, 2025, the Reporting Person was granted an award of up to 150,000 PSUs, which vests in the form of shares of the Issuer's common stock upon the achievement of certain financial milestones. On February 24, 2026, certain financial milestones were met, resulting in the vesting of the PSUs as to 120,000 of the underlying shares and the cancellation of the PSUs as to 30,000 of the underlying shares. /s/ Daniel Gordon Kirby 2026-02-26