X0508 4 2026-02-12 0 0001814114 Orchestra BioMed Holdings, Inc. OBIO 0001960418 Aiello Joshua C/O ORCHESTRA BIOMED HOLDINGS, INC. 150 UNION SQUARE DRIVE NEW HOPE PA 18938 0 1 0 0 Principal Accounting Officer 0 Stock Option (Right to Buy) 3.82 2026-02-12 4 A 0 70000 0 A 2036-02-12 Common Stock 70000 70000 D The stock options will vest as follows: (i) 25% of the stock options will vest on February 12, 2027 (the "Vesting Commencement Date") and (ii) the remaining 75% stock options will vest in equal installments every three months on the same day of the month as the Vesting Commencement Date, starting on May 12, 2027, subject to the Reporting Person's continuous service through such dates. /s/ Andrew Taylor, Attorney-in-Fact 2026-02-13