X0508 4 2026-02-03 0 0001374339 ProMIS Neurosciences Inc. PMN 0001927062 Kirwin Patrick D. C/O PROMIS NEUROSCIENCES INC. 1920 YONGE STREET, SUITE 200 TORONTO A6 M4S 3E2 ONTARIO, CANADA 1 0 0 0 0 Common Shares 2026-02-03 4 A 0 3050 12.13 A 5135 D Common Shares 1653 I By Patrick D. Kirwin Professional Corp Common Shares 305 I By his spouse Warrants to purchase Common Shares 14.40 2026-02-03 4 A 0 3050 A 2026-02-03 2031-02-03 Common Shares 3050 3050 D On February 3, 2026, pursuant to a Securities Purchase Agreement entered into by the Company with selected investors, the Reporting Person acquired 3,050 of the Company's common shares, no par value (the "Common Shares") and Common Share purchase warrants (the "Common Share Warrants") to purchase 3,050 Common Shares. The purchase price was $12.13 per Common Share and Common Share Warrant. Reflects a one-for-twenty-five reverse split of the Company's Common Shares effected on November 28, 2025. The Common Share Warrants will expire upon the earlier of (i) February 3, 2031 or (ii) within 60 days of the public announcement via press release or the filing of a Current Report on Form 8-K of topline data from the cohorts treated with single ascending doses of PMN310. /s/ Max A. Milbury, Attorney in Fact for Patrick Kirwin 2026-02-05