X0508 4 2026-01-12 0 0001682639 HYPERION DEFI, INC. HYPD 0002103610 Rubenstein Robert C/O HYPERION DEFI, INC. 23461 SOUTH POINTE DRIVE, SUITE 390 LAGUNA HILLS CA 92653 0 1 0 0 General Counsel 0 Common Stock, par value $0.0001 2026-01-12 4 A 0 75000 0 A 75000 D Represents restricted stock units ("RSUs") that vest as follows: (1) 37,500 RSUs shall vest on January 12, 2027 and (2) 37,500 RSUs shall vest in equal installments of 9,375 RSUs beginning three months after January 12, 2027 and continuing every three months thereafter until fully vested, subject to the Reporting Person's continued employment with the Company through each such vesting date. /s/ Robert Rubenstein 2026-01-12