X0508 4 2025-12-10 0 0001124524 Cryoport, Inc. CYRX 0001611439 Mandalam Ramkumar C/O CRYOPORT INC. 112 WESTWOOD PLACE, SUITE 350 BRENTWOOD TN 37027 1 0 0 0 0 Common Stock 2025-12-10 4 S 0 11570 9.9862 D 80758 D The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $9.93 to $10.0696, inclusive. With respect to prices reported as weighted average prices in Table I, the reporting person undertakes to provide to Cryoport, Inc., any security holder of Cryoport, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in the applicable footnotes to this Form 4. /s/ Ramkumar Mandalam 2025-12-12