X0508 4 2025-11-20 0 0001689548 Praxis Precision Medicines, Inc. PRAX 0001827760 Nemiroff Alex C/O PRAXIS PRECISION MEDICINES, INC. 99 HIGH STREET, 30TH FLOOR BOSTON MA 02110 0 1 0 0 General Counsel and Secretary 0 Common Stock 2025-11-20 4 M 0 1714 83.85 A 22545.667 D Common Stock 2025-11-20 4 M 0 6230 133.65 A 28775.667 D Common Stock 2025-11-20 4 M 0 2434 44.40 A 31209.667 D Common Stock 2025-11-20 4 M 0 5652 44.40 A 36861.667 D Common Stock 2025-11-20 4 M 0 9100 56.94 A 45961.667 D Common Stock 2025-11-20 4 S 0 1714 190.863 D 44247.667 D Common Stock 2025-11-20 4 S 0 13339 192.533 D 30908.667 D Common Stock 2025-11-20 4 S 0 977 193.233 D 29931.667 D Common Stock 2025-11-20 4 S 0 9100 194.30 D 20831.667 D Stock Option (Right to Buy) 83.85 2025-11-20 4 M 0 1714 0.00 D 2030-06-04 Common Stock 1714 0 D Stock Option (Right to Buy) 133.65 2025-11-20 4 M 0 6230 0.00 D 2030-09-13 Common Stock 6230 0 D Stock Option (Right to Buy) 44.40 2025-11-20 4 M 0 2434 0.00 D 2023-01-12 2033-01-12 Common Stock 2434 0 D Stock Option (Right to Buy) 44.40 2025-11-20 4 M 0 5652 0.00 D 2033-01-12 Common Stock 5652 2347 D Stock Option (Right to Buy) 56.94 2025-11-20 4 M 0 9100 0.00 D 2034-07-29 Common Stock 9100 19717 D The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $190.720 to $191.540. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote. The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $192.003 to $193.000. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote. The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $193.010 to $193.960. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote. This option was fully vested as of January 1, 2024. This option was fully vested as of September 9, 2024. The shares underlying this stock option vested as to 25% on January 12, 2024 and the remaining shares vest in substantially equal monthly installments over the following 36 months, subject to the Reporting Person's continued service through each vesting date. The shares underlying this stock option vested as to 7/48ths on July 29, 2024 and the remaining shares vest in substantially equal monthly installments over the following 41 months, subject to the Reporting Person's continued service through each vesting date. The transactions reported in this Form 4 were effected for estate planning purposes. /s/ Alex Nemiroff 2025-11-21