X0508 4 2025-11-03 0 0001080014 Innoviva, Inc. INVA 0001813426 Raifeld Pavel 1350 OLD BAYSHORE HIGHWAY, SUITE 400 BURLINGAME CA 94010 0 0 1 0 0 Common Stock 2025-05-15 4 A 0 1860 0 A 51840 D Common Stock 2025-11-03 4 A 0 110436 18.11 A 162276 D Includes 1.860 shares of common stock acquired under the Innoviva, Inc. Employee Stock Purchase Plan on May 15, 2025. The Reporting Person was granted a time-vested restricted stock unit ("RSU"). Twenty-five percent of the shares subject to the RSU vest on November 20, 2026 and the balance will vest in twelve (12) substantially equal installments thereafter on each three (3) month anniversary of the initial vesting date, in each case, provided the Reporting Person has provided continuous service to the Issuer through the applicable vesting date, with accelerated vesting (i) in the event of a "change in control" (as defined in the Issuer's 2012 Equity Incentive Plan) in which the RSU is not assumed or replaced, or (ii) in the event that the Reporting Person experiences an "involuntary termination" of employment within 24 months following a "change in control," subject to an effective release of claims. The grant was approved by the Compensation Committee of the Board of Directors of the Company. /s/ Pavel Raifeld 2025-11-05