SEC FORM 4

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

OYLER JOHN

(Last)

(First)

(Middle)

C/O BEONE MEDICINES I GMBH

AESCHENGRABEN 27, 21ST FLOOR

(Street)

BASEL

4051

(City)

(State)

(Zip)

SWITZERLAND

(Country)

2. Issuer Name and Ticker or Trading Symbol
BeOne Medicines Ltd. [ ONC ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director	10% Owner
X	Officer (give title below)	Other (specify below)
	Chief Executive Officer

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
07/15/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Ordinary Shares								5,445,917	D
Ordinary Shares								481,533	I	See Footnote⁽¹⁾
Ordinary Shares								7,699,158	I	See Footnote⁽²⁾
Ordinary Shares								28,204,115	I	See Footnote⁽³⁾
Ordinary Shares								9,545,000	I	See Footnote⁽⁴⁾
Ordinary Shares								102,188	I	See Footnote⁽⁵⁾
American Depositary Shares⁽⁶⁾	07/15/2026		M		35,605	A	$100.04	35,605	D
American Depositary Shares⁽⁶⁾	07/15/2026		M		76,677	A	$169.58	112,282	D
American Depositary Shares⁽⁶⁾	07/15/2026		M		4,275	A	$160.4	116,557	D
American Depositary Shares⁽⁶⁾	07/15/2026		S⁽⁷⁾		6,067	D	$310.0201⁽⁸⁾	110,490	D
American Depositary Shares⁽⁶⁾	07/15/2026		S⁽⁷⁾		41,336	D	$310.9228⁽⁹⁾	69,154	D
American Depositary Shares⁽⁶⁾	07/15/2026		S⁽⁷⁾		12,857	D	$311.7123⁽¹⁰⁾	56,297	D
American Depositary Shares⁽⁶⁾	07/15/2026		S⁽⁷⁾		48,657	D	$312.8583⁽¹¹⁾	7,640	D
American Depositary Shares⁽⁶⁾	07/15/2026		S⁽⁷⁾		7,640	D	$313.5793⁽¹²⁾	0	D
American Depositary Shares⁽⁶⁾	07/16/2026		M		96,501	A	$160.4	96,501	D
American Depositary Shares⁽⁶⁾	07/16/2026		M		70,096	A	$119.96	166,597	D
American Depositary Shares⁽⁶⁾	07/16/2026		S⁽⁷⁾		233	D	$311.98	166,364	D
American Depositary Shares⁽⁶⁾	07/16/2026		S⁽⁷⁾		4,881	D	$314.0772⁽¹³⁾	161,483	D
American Depositary Shares⁽⁶⁾	07/16/2026		S⁽⁷⁾		9,516	D	$314.7318⁽¹⁴⁾	151,967	D
American Depositary Shares⁽⁶⁾	07/16/2026		S⁽⁷⁾		19,752	D	$316⁽¹⁵⁾	132,215	D
American Depositary Shares⁽⁶⁾	07/16/2026		S⁽⁷⁾		32,224	D	$316.8173⁽¹⁶⁾	99,991	D
American Depositary Shares⁽⁶⁾	07/16/2026		S⁽⁷⁾		42,798	D	$317.7887⁽¹⁷⁾	57,193	D
American Depositary Shares⁽⁶⁾	07/16/2026		S⁽⁷⁾		6,402	D	$318.5493⁽¹⁸⁾	50,791	D
American Depositary Shares⁽⁶⁾	07/16/2026		S⁽⁷⁾		15,097	D	$319.993⁽¹⁹⁾	35,694	D
American Depositary Shares⁽⁶⁾	07/16/2026		S⁽⁷⁾		20,505	D	$320.998⁽²⁰⁾	15,189	D
American Depositary Shares⁽⁶⁾	07/16/2026		S⁽⁷⁾		13,109	D	$321.6127⁽²¹⁾	2,080	D
American Depositary Shares⁽⁶⁾	07/16/2026		S⁽⁷⁾		1,560	D	$322.7076⁽²²⁾	520	D
American Depositary Shares⁽⁶⁾	07/16/2026		S⁽⁷⁾		520	D	$323.5858⁽²³⁾	0	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)		10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
Share Option (Right to Buy)	$7.7⁽²⁴⁾	07/15/2026		M			462,865	⁽²⁵⁾	09/26/2027	Ordinary Shares	462,865	$0	1	D
Share Option (Right to Buy)	$13.05⁽²⁴⁾	07/15/2026		M			996,801	⁽²⁶⁾	04/29/2028	Ordinary Shares	996,801	$0	9	D
Share Option (Right to Buy)	$12.34⁽²⁴⁾	07/15/2026		M			55,575	⁽²⁷⁾	06/25/2028	Ordinary Shares	55,575	$0	1,254,513	D
Share Option (Right to Buy)	$12.34⁽²⁴⁾	07/16/2026		M			1,254,513	⁽²⁷⁾	06/25/2028	Ordinary Shares	1,254,513	$0	0	D
Share Option (Right to Buy)	$9.23⁽²⁴⁾	07/16/2026		M			911,248	⁽²⁸⁾	06/04/2029	Ordinary Shares	911,248	$0	1,282,034	D

Explanation of Responses:

1. These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership.

2. These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

3. These securities are held by Oyler Investment LLC, of which 99% of the the limited liability company interests are owned by a grantor retain annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.

4. These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account.

5. These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's child, for which the Reporting Person disclaims beneficial ownership.

6. Each American Depositary Share represents 13 Ordinary Shares.

7. The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

8. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $309.31 to $310.30, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

9. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $310.35 to $311.34, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

10. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $311.35 to $312.34, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

11. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $312.35 to $313.345, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

12. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $313.36 to $313.90, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

13. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $313.27 to $314.26, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

14. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $314.27 to $315.24, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

15. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $315.28 to $316.27, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

16. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $316.28 to $317.27, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

17. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $317.28 to $318.265, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

18. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $318.30 to $319.11, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

19. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $319.36 to $320.34, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

20. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $320.38 to $321.35, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

21. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $321.39 to $322.33, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

22. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $322.455 to $323.405, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

23. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $323.495 to $323.625, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

24. The number of securities underlying each option and the exercise price therefore are represented in ordinary shares.

25. These securities vest over a four-year period as follows: 25% on June 30, 2018, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

26. These securities vest over a four-year period as follows: 25% on April 30, 2019, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

27. These securities vest over a four-year period as follows: 25% on June 26, 2019, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

28. These securities vest over a four-year period as follows: 25% on June 5, 2020, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

Remarks:

	/s/ Frank Collazo, as Attorney-in-Fact	07/17/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)