X0609 4 2026-07-10 0 0001651308 BeOne Medicines Ltd. ONC 0001042047 OYLER JOHN true C/O BEONE MEDICINES I GMBH AESCHENGRABEN 27, 21ST FLOOR BASEL V8 4051 SWITZERLAND 1 1 0 0 Chief Executive Officer 1 Ordinary Shares 5605310 D Ordinary Shares 481533 I See Footnote Ordinary Shares 7699158 I See Footnote Ordinary Shares 28204115 I See Footnote Ordinary Shares 9545000 I See Footnote Ordinary Shares 102188 I See Footnote American Depositary Shares 2026-07-10 4 M 0 11698 36.90 A 11698 D American Depositary Shares 2026-07-10 4 S 0 1493 296.0672 D 10205 D American Depositary Shares 2026-07-10 4 S 0 1314 297.2303 D 8891 D American Depositary Shares 2026-07-10 4 S 0 3074 298.3516 D 5817 D American Depositary Shares 2026-07-10 4 S 0 5143 298.9362 D 674 D American Depositary Shares 2026-07-10 4 S 0 370 300.1199 D 304 D American Depositary Shares 2026-07-10 4 S 0 150 301.1828 D 154 D American Depositary Shares 2026-07-10 4 S 0 136 302.1911 D 18 D American Depositary Shares 2026-07-10 4 S 0 18 303.03 D 0 D American Depositary Shares 2026-07-13 4 M 0 48520 36.90 A 48520 D American Depositary Shares 2026-07-13 4 S 0 798 301.9364 D 47722 D American Depositary Shares 2026-07-13 4 S 0 4584 302.7881 D 43138 D American Depositary Shares 2026-07-13 4 S 0 26294 303.8251 D 16844 D American Depositary Shares 2026-07-13 4 S 0 8438 304.6803 D 8406 D American Depositary Shares 2026-07-13 4 S 0 846 305.5654 D 7560 D American Depositary Shares 2026-07-13 4 S 0 7240 306.8245 D 320 D American Depositary Shares 2026-07-13 4 S 0 320 307.405 D 0 D Share Option (Right to Buy) 2.84 2026-07-10 4 M 0 152074 0 D 2026-11-15 Ordinary Shares 152074 1895426 D Share Option (Right to Buy) 2.84 2026-07-13 4 M 0 630760 0 D 2026-11-15 Ordinary Shares 630760 1264666 D These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership. These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership. These securities are held by Oyler Investment LLC, of which 99% of the the limited liability company interests are owned by a grantor retain annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership. These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account. These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's child, for which the Reporting Person disclaims beneficial ownership. Each American Depositary Share represents 13 Ordinary Shares. The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $295.66 to $296.65, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $296.66 to $297.64, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $297.67 to $298.66, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $298.68 to $299.59, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $299.68 to $300.61, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $300.69 to $301.47, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $301.95 to $302.25, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $301.23 to $302.19, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $302.29 to $303.27, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $303.30 to $304.29, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $304.30 to $305.26, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $305.30 to $306.23, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $306.32 to $307.26, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $307.35 to $307.44, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. These securities vest over a four-year period as follows: 25% on July 13, 2017, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares subject to this option are subject to accelerated vesting upon a change in control or certain termination events. Exhibit List - Exhibit 24.1 - Power of Attorney /s/ Frank Collazo, as Attorney-in-Fact 2026-07-14