X0508 4 2026-03-06 0 0001651308 BeOne Medicines Ltd. ONC 0001042047 OYLER JOHN C/O BEONE MEDICINES I GMBH AESCHENGRABEN 27, 21ST FLOOR BASEL V8 4051 SWITZERLAND 1 1 0 0 Chief Executive Officer 0 Ordinary Shares 2026-03-06 4 A 0 326976 0 A 5491339 D Ordinary Shares 2026-03-06 4 A 0 117936 0 A 5609275 D Ordinary Shares 481533 I See Footnote Ordinary Shares 7699158 I See Footnote Ordinary Shares 28204115 I See Footnote Ordinary Shares 9545000 I See Footnote Ordinary Shares 102188 I See Footnote Represents the total number of ordinary shares underlying the performance share units earned by Reporting Person. The earned performance share units will vest in 2027, subject to the Reporting Person continuing to provide service to the Company through such vesting date. Unvested shares are subject to accelerated vesting upon change of control or certain termination events. Represents the total number of ordinary shares underlying the performance share units earned by Reporting Person. The earned performance share units will vest in 2028, subject to the Reporting Person continuing to provide service to the Company through such vesting date. Unvested shares are subject to accelerated vesting upon change of control or certain termination events. These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership. These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership. These securities are held by Oyler Investment LLC, of which 99% of the the limited liability company interest owned by a grantor retain annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership. These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account. These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's minor child, for which the Reporting Person disclaims beneficial ownership. /s/ Qing Nian, as Attorney-in-Fact 2026-03-10