X0609 4 2026-10-06 1 0001023459 Simulations Plus, Inc. SLP 0001899498 Evans Sharlene false 600 PARK OFFICES DRIVE SUITE 300 #4134 DURHAM NC 27713 1 0 0 0 0 Common Stock 2026-10-06 4 D 0 17173 18.50 D 0 D This Form 4 reports securities disposed of pursuant to the terms of the Agreement and Plan of Merger, dated as of June 15, 2026 (the "Merger Agreement"), by and among Simulations Plus, Inc. (the "Issuer"), SP Evolution HoldCo II, LLC ("Parent") and SP Evolution BidCo II, LLC, a wholly owned subsidiary of Parent ("Merger Sub"), pursuant to which Merger Sub merged with and into the Issuer (the "Merger"), with the Issuer surviving the Merger as a wholly owned subsidiary of Parent. At the effective time of the Merger (the "Effective Time"), each share of common stock of the Issuer issued and outstanding immediately prior to the Effective Time (other than certain excluded shares specified in the Merger Agreement) was automatically converted into the right to receive $18.50 in cash, without interest. /s/ William Frederick, attorney-in-fact for Sharlene Evans 2026-10-06