X0609 4 2026-10-06 1 0001023459 Simulations Plus, Inc. SLP 0001269890 FREDERICK WILLIAM W false 600 PARK OFFICES DRIVE SUITE 300 #4134 DURHAM NC 27713 0 1 0 0 EVP/CFO 0 Common Stock 2026-10-06 4 D 0 2100 18.50 D 0 D Stock Options (Right to Buy) 16.02 2026-10-06 4 D 0 32500 D 2035-10-15 Common Stock 32500 0 D Stock Options (Right to Buy) 43.91 2026-10-06 4 D 0 20000 D 2032-10-19 Common Stock 20000 0 D Stock Options (Right to Buy) 56.40 2026-10-06 4 D 0 20000 D 2030-12-01 Common Stock 20000 0 D Stock Options (Right to Buy) 39.98 2026-10-06 4 D 0 25000 D 2033-10-18 Common Stock 25000 0 D Stock Options (Right to Buy) 33.29 2026-10-06 4 D 0 10000 D 2034-10-16 Common Stock 10000 0 D This Form 4 reports securities disposed of pursuant to the terms of the Agreement and Plan of Merger, dated as of June 15, 2026 (the "Merger Agreement"), by and among Simulations Plus, Inc. (the "Issuer"), SP Evolution HoldCo II, LLC ("Parent") and SP Evolution BidCo II, LLC, a wholly owned subsidiary of Parent ("Merger Sub"), pursuant to which Merger Sub merged with and into the Issuer (the "Merger"), with the Issuer surviving the Merger as a wholly owned subsidiary of Parent. At the effective time of the Merger (the "Effective Time"), each share of common stock of the Issuer ("Company Common Stock") issued and outstanding immediately prior to the Effective Time (other than certain excluded shares specified in the Merger Agreement) was automatically converted into the right to receive $18.50 in cash, without interest (the "Merger Consideration"). Pursuant to the Merger Agreement, effective as of or immediately prior to the Effective Time, each option to purchase shares of Company Common Stock (each, a "Company Option") that was outstanding immediately prior to the Effective Time automatically vested and was canceled and converted into the right to receive an amount in cash, without interest, equal to (i) the number of shares of Company Common Stock subject to such Company Option immediately prior to the Effective Time multiplied by (ii) the excess, if any, of the Merger Consideration over the applicable exercise price per share of Company Common Stock subject to such Company Option. Each Company Option with an exercise price per share greater than or equal to the Merger Consideration was canceled for no consideration. Any such Company Option with a per share exercise price that was equal to or greater than the Merger Consideration was canceled by virtue of the Merger without any payment to the reporting person. /s/ William Frederick 2026-10-06