X0609 4 2026-06-18 0001818331 GeneDx Holdings Corp. WGS 0000943431 RUCH JOSHUA false C/O GENEDX HOLDINGS CORP. 333 LUDLOW ST., NORTH TOWER, 6TH FLOOR STAMFORD CT 06902 true false false false 0 Class A Common Stock 2026-06-18 4 M 0 3576 0 A 33299 D Class A Common Stock 11941 I By Kariba LLC Class A Common Stock 24243 I By Rugu2 LLC Class A Common Stock 120083 I By VAAL Investment Partners Q9 LP Restricted Stock Unit 2026-06-18 4 A 0 4248 0 A Class A Common Stock 4248 4248 D Restricted Stock Unit 2026-06-18 4 M 0 3576 0 D Class A Common Stock 3576 0 D Each restricted stock unit ("RSU") represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration. The Reporting Person is a managing member of: (i) Kariba LLC ("Kariba"); (ii) RUGU2 LLC ("RUGU2"); and (iii) the managing member of the general partner of Vaal Investment Partners Q9 LP ("Q9"). As such, the Reporting Person may be deemed to exercise voting and investment discretion with respect to securities directly held by Kariba, RUGU2, and Q9. The Reporting Person disclaims beneficial ownership of such securities, except to the extent of his pecuniary interest therein. The entire award shall vest on the earlier of the (i) date of the 2027 annual meeting of the Issuer's stockholders, or (ii) first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer through the vesting date. These RSUs do not have an expiration date; they either vest or are cancelled prior to the vesting date. The entire award vested or vests on the earlier of the: (i) date of the 2026 annual meeting of the Issuer's stockholders, or (ii) first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer through the vesting date. These RSUs do not have an expiration date; they either vest or are cancelled prior to the vesting date. /s/ Bridget Brown, Attorney-in-Fact 2026-06-23