X0508 4 2025-11-24 0001818331 GeneDx Holdings Corp. WGS 0000943431 RUCH JOSHUA C/O GENEDX HOLDINGS CORP. 333 LUDLOW ST., NORTH TOWER, 6TH FLOOR STAMFORD CT 06902 true false false false 0 Class A Common Stock 2025-11-24 4 S 0 201 158.4039 D 14644 I Kariba LLC Class A Common Stock 2025-11-24 4 S 0 625 159.2758 D 14019 I Kariba LLC Class A Common Stock 2025-11-24 4 S 0 889 160.4494 D 13130 I Kariba LLC Class A Common Stock 2025-11-24 4 S 0 1117 161.1569 D 12013 I Kariba LLC Class A Common Stock 2025-11-24 4 S 0 72 162.0390 D 11941 I Kariba LLC Class A Common Stock 2025-11-24 4 S 0 407 158.4039 D 29731 I Rugu2 LLC Class A Common Stock 2025-11-24 4 S 0 1268 159.2758 D 28463 I Rugu2 LLC Class A Common Stock 2025-11-24 4 S 0 1805 160.4494 D 26658 I Rugu2 LLC Class A Common Stock 2025-11-24 4 S 0 2268 161.1569 D 24390 I Rugu2 LLC Class A Common Stock 2025-11-24 4 S 0 147 162.0390 D 24243 I Rugu2 LLC Class A Common Stock 2025-11-24 4 S 0 2016 158.4039 D 147268 I VAAL Investment Partners Q9 LP Class A Common Stock 2025-11-24 4 S 0 6279 159.2758 D 140989 I VAAL Investment Partners Q9 LP Class A Common Stock 2025-11-24 4 S 0 8944 160.4494 D 132045 I VAAL Investment Partners Q9 LP Class A Common Stock 2025-11-24 4 S 0 11234 161.1569 D 120811 I VAAL Investment Partners Q9 LP Class A Common Stock 2025-11-24 4 S 0 728 162.039 D 120083 I VAAL Investment Partners Q9 LP Class A Common Stock 29723 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $157.80 to $158.79, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnotes 3 through 6 of this Form 4. Mr. Ruch is (i) a managing member of the managing member of the general partner of Vaal Investment Partners Q9 LP ("Q9"), (ii) a managing member of RUGU2 LLC ("RUGU2") and (iii) a managing member of Kariba LLC ("Kariba"). As such, Mr. Ruch exercises voting and investment power with respect to the shares owned by Q9, RUGU2 and Kariba. Mr. Ruch disclaims beneficial ownership of such securities, except to the extent of his pecuniary interest therein. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $158.84 to $159.83, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $159.85 to $160.835, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $160.85 to $161.84, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $161.85 to $162.175, inclusive. /s/ Bridget Brown, Attorney-in-Fact 2025-11-26