<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0609</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2026-03-26</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0001671502</issuerCik>
        <issuerName>Quoin Pharmaceuticals, Ltd.</issuerName>
        <issuerTradingSymbol>QNRX</issuerTradingSymbol>
        <issuerForeignTradingSymbol></issuerForeignTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001440771</rptOwnerCik>
            <rptOwnerName>Stonepine Capital Management, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerNonUSAddressFlag>false</rptOwnerNonUSAddressFlag>
            <rptOwnerStreet1>2900 NW CLEARWATER DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 100-11</rptOwnerStreet2>
            <rptOwnerCity>BEND</rptOwnerCity>
            <rptOwnerState>OR</rptOwnerState>
            <rptOwnerZipCode>97703</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <remarks>On March 26, 2026, the Issuer filed a Form 10-K reporting it has 63,126,930 Ordinary Shares outstanding, represented by 1,803,626 American Depositary Shares outstanding. All of the warrants owned by the reporting person are subject to a 9.99% beneficial ownership limitation. As a result of the change in the number of Ordinary Shares outstanding, the reporting person has ceased to beneficially own more than 10% of the outstanding Ordinary Shares.</remarks>

    <ownerSignature>
        <signatureName>/s/ Jon M. Plexico, Managing Member of Stonepine Capital Management, LLC</signatureName>
        <signatureDate>2026-03-31</signatureDate>
    </ownerSignature>
</ownershipDocument>
