X0609 4 2026-06-24 0 0001590560 uniQure N.V. QURE 0001536290 Kapusta Matthew C true C/O UNIQURE N.V. PAASHEUVELWEG 25A AMSTERDAM P7 1105BP NETHERLANDS 1 1 0 0 CEO, Managing Director 1 Ordinary Shares 2026-06-24 4 M 0 4128 31.71 A 525923 D Ordinary Shares 2026-06-24 4 S 0 6696 50.00 D 519227 D Ordinary Shares 2026-06-25 4 M 0 28716 31.71 A 547943 D Ordinary Shares 2026-06-25 4 S 0 28716 50.02 D 519227 D Stock Option (Right to Buy) 31.71 2026-06-24 4 M 0 4128 0 D 2029-01-25 Ordinary Shares 4128 74578 D Stock Option (Right to Buy) 31.71 2026-06-25 4 M 0 28716 0 D 2029-01-25 Ordinary Shares 28716 45862 D The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on October 5, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $50.00 to $50.30. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The Stock Option vested in full on January 25, 2023. /s/ Christian Klemt, Attorney-in-Fact 2026-06-26