X0508 4 2026-02-27 0000882796 BIOCRYST PHARMACEUTICALS INC BCRX 0001385496 Stonehouse Jon P 4505 EMPEROR BLVD. SUITE 200 DURHAM NC 27703 1 1 Common Stock 2026-02-27 4 A 0 421 8.75 A 1323850 D Common Stock 2026-03-02 4 M 0 305995 3.22 A 1629845 D Common Stock 2026-03-02 4 D 0 305995 8.64 D 1323850 D Common Stock 40000 I By wife as co-trustee of the Caroline Stonehouse Irrevocable Trust Common Stock 40000 I By wife as co-trustee of the Samuel Stonehouse Irrevocable Trust Emp. Stock Option (Right to Buy) 3.22 2026-03-02 4 M 0 305995 0 D 2017-05-23 2026-05-23 Common Stock 305995 0 D Shares of Common Stock issued to the reporting person in lieu of 50% of the prorated quarterly cash Board Member retainer of $7,375. This transaction was made pursuant to a plan adopted by the reporting person on November 28, 2022, as modified on May 13, 2024 and further modified on May 29, 2024, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The options were originally granted to the reporting person on May 23, 2016 and would have expired on May 23, 2026. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person. The price in column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $8.54 to $8.81. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote. /s/ Alane P. Barnes, by power of attorney 2026-03-03