X0508 4 2025-12-16 0 0000805928 Axogen, Inc. AXGN 0001979466 Weiler Kathy Johnson C/O AXOGEN, INC. 13631 PROGRESS BLVD., SUITE 400 ALACHUA FL 32615 1 0 0 0 0 Common Stock 2025-12-16 4 M 0 18248 7.04 A 24828 D Common Stock 2025-12-16 4 M 0 21825 6.95 A 46653 D Common Stock 2025-12-16 4 S 0 18248 29.547 D 28405 D Common Stock 2025-12-16 4 S 0 21825 29.547 D 6580 D Common Stock 2025-12-16 4 S 0 6580 29.55 D 0 D Employee Stock Option (right to purchase) 7.04 2025-12-16 4 M 0 18248 0 D 2034-06-06 Common Stock 18248 0 D Employee Stock Option (right to purchase) 6.95 2025-12-16 4 M 0 21825 0 D 2033-12-20 Common Stock 21825 43651 D The reported price in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $29.01 to $30.00 per share. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. Non-qualified stock option portion of the annual equity grant for service as Director on the Axogen, Inc. Board of Directors. The grant fully vested on June 6, 2025, the one-year anniversary of the date of the grant. Option grant for joining the Issuer's Board of Directors. Options vest in three equal annual installments on the annual anniversary of the grant date with the first vesting date occurring on December 20, 2024. /s/ Marc Began, as attorney-in-fact for Kathy Weiler 2025-12-17