X0508 4 2025-12-15 0 0000805928 Axogen, Inc. AXGN 0002068693 Hartley Lindsey Marie 13631 PROGRESS BLVD. SUITE 400 ALACHUA FL 32615 0 1 0 0 CFO 0 Common Stock 2025-12-15 4 M 0 14812 8.27 A 46188 D Common Stock 2025-12-15 4 S 0 14812 29.8605 D 31376 D Employee Stock Option (right to purchase) 8.27 2025-12-15 4 M 0 14812 0 D 2033-03-16 Common Stock 14812 0 D The reported price in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $29.875 to $29.860 per share. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. All shares of Axogen, Inc. common stock underlying the employee stock option will be fully vested on March 16, 2027 (4 years from the option grant date) based upon a vesting schedule whereby 50% of the aggregate shares vested on March 16, 2025 (24 months from the option grant date) and an additional 12.5% of the aggregate shares vest each 6 months thereafter. /s/ Marc Began, as attorney-in-fact for Lindsey Hartley 2025-12-17