X0508 4 2025-10-29 0 0000805928 Axogen, Inc. AXGN 0001682069 Burke William P. Mr. C/O AXOGEN, INC. 13631 PROGRESS BLVD. SUITE 400 ALACHUA FL 32615 1 0 0 0 1 Common Stock 2025-10-29 2025-10-29 4 M 0 20436 6.30 A 20536 D Common Stock 2025-10-29 2025-10-29 4 S 0 20436 19.1542 D 100 D Common Stock 2025-10-29 2025-10-29 4 M 0 19799 8.14 A 19899 D Common Stock 2025-10-29 2025-10-29 4 S 0 19799 22 D 100 D Common Stock 2025-10-30 2025-10-30 4 M 0 18248 7.04 A 18348 D Common Stock 2025-10-30 2025-10-30 4 S 0 18248 23 D 100 D Stock Option (right to buy) 6.30 2025-10-29 2025-10-29 4 M 0 20436 0 D 2033-09-01 Common Stock 20436 0 D Stock Option (right to purchase) 8.14 2025-10-29 2025-10-29 4 M 0 19799 0 D 2032-07-11 Common Stock 19799 39596 D Employee Stock Option (right to purchase) 7.04 2025-10-30 2025-10-30 4 M 0 18248 0 D 2034-06-06 Common Stock 18248 0 D The sale reported on this Form 4 was made pursuant to a Rule 10b5-1(c) trading plan adopted March 14, 2025. The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $19.00 to $19.50 per share. The Reporting Person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price. The sale reported on this Form 4 was made pursuant to a Rule 10b5-1(c) trading plan adopted March 14, 2025. This grant vested on the first anniversary of the date of the grant, September 1, 2023. This grant vested in three equal annual installments on the annual anniversary of the grant date, July 11, 2022. This grant vested on the first anniversary of the date of the grant, June 6, 2024. /s/ Marc Began, as attorney-in-fact for William Burke 2025-10-31