X0609 4 2026-08-20 0 0000097745 THERMO FISHER SCIENTIFIC INC. TMO 0001216055 CASPER MARC N false 168 THIRD AVENUE WALTHAM MA 02451 1 1 0 0 Chairman & CEO 1 Common Stock 2026-08-20 4 M 0 10000 309.63 A 133925.358 D Common Stock 2026-08-20 4 S 0 909 625.45 D 133016.358 D Common Stock 2026-08-20 4 S 0 821 626.83 D 132195.358 D Common Stock 2026-08-20 4 S 0 1314 627.66 D 130881.358 D Common Stock 2026-08-20 4 S 0 2601 628.82 D 128280.358 D Common Stock 2026-08-20 4 S 0 1250 629.85 D 127030.358 D Common Stock 2026-08-20 4 S 0 1035 630.87 D 125995.358 D Common Stock 2026-08-20 4 S 0 1430 632.01 D 124565.358 D Common Stock 2026-08-20 4 S 0 560 632.94 D 124005.358 D Common Stock 2026-08-20 4 S 0 80 633.99 D 123925.358 D Common Stock 2026-08-21 4 M 0 10000 309.63 A 133925.358 D Common Stock 2026-08-21 4 S 0 2727 625.46 D 131198.358 D Common Stock 2026-08-21 4 S 0 3014 626.51 D 128184.358 D Common Stock 2026-08-21 4 S 0 1791 627.39 D 126393.358 D Common Stock 2026-08-21 4 S 0 2147 628.61 D 124246.358 D Common Stock 2026-08-21 4 S 0 321 629.10 D 123925.358 D Common Stock 11300 I By Alison Casper 2020 Irrevocable Trust Common Stock 5000 I By MNC 2020 Irrevocable Trust Stock Option (Right to Buy) 309.63 2026-08-20 4 M 0 10000 0 D 2027-02-25 Common Stock 10000 10275 D Stock Option (Right to Buy) 309.63 2026-08-21 4 M 0 10000 0 D 2027-02-25 Common Stock 10000 275 D The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on April 27, 2026. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $625.00 to $625.80, inclusive. The reporting person undertakes to provide to Thermo Fisher Scientific Inc. ("TMO"), any security holder of TMO or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), (13) and (14) to this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $626.17 to $627.08, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $627.33 to $628.29, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $628.36 to $629.33, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $629.41 to $630.37, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $630.47 to $631.37, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $631.52 to $632.44, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $632.60 to $633.32, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $625.00 to $625.97, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $626.00 to $626.99, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $627.00 to $627.99, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $628.00 to $628.94, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $629.00 to $629.20, inclusive. The reporting person disclaims beneficial ownership of the securities reported herein as indirectly beneficially owned, except to the extent of any pecuniary interest therein. The option vested in four equal installments on February 25, 2021, 2022, 2023, and 2024. /s/ Melodie T. Morin, Attorney-in-Fact for Marc N. Casper 2026-08-24